Abstract Introduction: The objective was to conduct a systematic review of economic assessment of interventional strategies, in the prevention of frailty in elderly of 60 years and over living at home. Methods: The keywords were searched in databases such as Pubmed, ScienceDirect, Google Scholar and Embase. Articles published in English and French between 31/10/2010 and 31/12/2021 were included. The CHEERS statement reading grid was used to assess the quality of the studies in terms of economic assessments. Results: The search had identified nine relevant research studies, including seven randomised controlled trials and two quasi-experimental studies. Of these studies, we classified them into three programs: five studies on frailty screening, three studies on falls prevention and one study on the analysis of drugs and treatments prescribed and delivered. According to the cost-effectiveness plan of these programs, four studies had no conclusion on economic results, two studies had a dominant strategy, less expensive and more efficient, and three studies had a dominated strategy, more expensive and not efficient. Only 40% of the studies were of good quality. Conclusion: Only two multidimensional and interdisciplinary intervention strategies were highly efficient, cost-effective and improved the quality of life of elderly. Economic results were more mixed. Many methodological weaknesses were present in these studies.