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Article Dans Une Revue RSC Advances Année : 2023

A sustainable metal and base-free direct amidation of esters using water as a green solvent

Résumé

Herein, we report a simple and efficient synthetic approach for direct amidation of esters via C(acyl)-O bond cleavage without any additional reagents or catalysts, using only water as a green solvent. Subsequently, the reaction byproduct is recovered and utilized for the next phase of ester synthesis. This method emphasized metal-free, additive-free, and base-free characteristics making it a new, sustainable, and eco-friendly way to realize direct amide bond formation. In addition, the synthesis of the drug molecule diethyltoluamide and the Gram-scale synthesis of a representative amide are demonstrated.

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Chimie
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Dates et versions

hal-04115581 , version 1 (02-06-2023)

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Paternité - Pas d'utilisation commerciale

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Nanthini Rajendran, Kiruthigadevi Kamaraj, Saranya Janakiraman, Mary Saral, Pierre H. Dixneuf, et al.. A sustainable metal and base-free direct amidation of esters using water as a green solvent. RSC Advances, 2023, 13 (22), pp.14958-14962. ⟨10.1039/d3ra02637j⟩. ⟨hal-04115581⟩
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