IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2020

IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB

Résumé

IMGT ® , the international ImMunoGeneTics information system ® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT ® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT ® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γ δ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT ® biocurators for several veterinary species, i.e., cat (Felis catus), dog (Canis lupus familiaris), ferret (Mustela putorius furo), pig (Sus scrofa), rabbit (Oryctolagus cuniculus), rhesus monkey (Macaca mulatta), and sheep (Ovis aries). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on Homo sapiens. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.
Fichier principal
Vignette du fichier
fimmu-11-00821.pdf (8.93 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04113881 , version 1 (01-06-2023)

Licence

Identifiants

Citer

Perrine Pégorier, Morgane Bertignac, Imène Chentli, Viviane Nguefack Ngoune, Géraldine Folch, et al.. IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB. Frontiers in Immunology, 2020, 11 (821), ⟨10.3389/fimmu.2020.00821⟩. ⟨hal-04113881⟩
11 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More