NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Genomics Année : 2001

NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines

Résumé

We describe the isolation and characterization of NSD3, the third member of a gene family including Nsd1 and NSD2. Murine Nsd1 was isolated in a search for proteins that interact with the ligand-binding domain of retinoic acid receptor alpha. NSD2 (also known as WHSC1 and MMSET) is located in the Wolf-Hirschhorn syndrome (WHS) critical region on 4p16.3 and is involved in multiple myeloma with t(4;14) translocations. The proteins Nsd1, NSD2, and NSD3 are highly similar within a block of about 700 amino acids. This block contains several conserved domains, such as the SET domain and the PHD finger, present in proteins involved in development and/or chromatin reorganization. The NSD3 gene consists of an 8.5-kb transcript composed of 23 coding exons and spans >90 kb of genomic DNA. NSD3 maps to chromosome band 8p12 and is amplified in several tumor cell lines and primary breast carcinomas.

Domaines

Génétique

Dates et versions

hal-04112679 , version 1 (31-05-2023)

Identifiants

Citer

Pierre-Olivier Angrand, Françoise Apiou, A. Francis Stewart, Bernard Dutrillaux, Regine Losson, et al.. NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. Genomics, 2001, 74 (1), pp.79-88. ⟨10.1006/geno.2001.6524⟩. ⟨hal-04112679⟩
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