Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis - Archive ouverte HAL Access content directly
Journal Articles Journal of Molecular Endocrinology Year : 2001

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.
No file

Dates and versions

hal-04112341 , version 1 (31-05-2023)

Identifiers

Cite

L Fajas, Mb Debril, J Auwerx. Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. Journal of Molecular Endocrinology, 2001, 27 (1), pp.1-9. ⟨10.1677/jme.0.0270001⟩. ⟨hal-04112341⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More