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Article Dans Une Revue Lab on a Chip Année : 2023

Microfluidic in-line dynamic light scattering with a commercial fibre optic system

Résumé

We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free fibre-optic system, enabling the under-flow characterisation of a range of solutions, dispersions, and structured fluids. The system is evaluated and validated with model systems, specifically micellar and (dilute) polymer solutions, and colloidal dispersions of different radii (∼1–100 nm). A systematic method of flow-DLS analysis is examined as a function of flow velocity (0–16 cm s−1), and considerations of the relative contribution of ‘transit’ and ‘Brownian’ terms enable the identification of regions where (i) a quiescent approximation suffices, (ii) the flow-DLS framework holds, as well as (iii) where deviations are found, until eventually (iv) the convection dominates. We investigate practically relevant, robust setups, namely that of a capillary connected to microdevice, as well as direct measurement on a glass microdevice, examining the role of capillary dimensions and challenges of optical alignment. We conclude with a demonstration of a continuous flow measurement of a binary surfactant/salt solution, whose micellar dimensions vary with composition, characterised with hundreds of data points (every ∼5 s) and adequate statistics, within a few minutes.

Domaines

Chimie

Dates et versions

hal-04109364 , version 1 (30-05-2023)

Licence

Paternité

Identifiants

Citer

Luis Torquato, Nelson Hélaine, Yufan Cui, Roisin O'Connell, Jérémie Gummel, et al.. Microfluidic in-line dynamic light scattering with a commercial fibre optic system. Lab on a Chip, 2023, 11, pp.2540-2552. ⟨10.1039/d3lc00062a⟩. ⟨hal-04109364⟩
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