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Article Dans Une Revue BMC Medicine Année : 2023

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Jelena Bešević
  • Fonction : Auteur
Inge Huybrechts
  • Fonction : Auteur
Cornelia Prehn
Jerzy Adamski
  • Fonction : Auteur
Amanda Jane Cross
  • Fonction : Auteur
Hector Charles Keun
  • Fonction : Auteur
Marc Chadeau-Hyam
  • Fonction : Auteur
Kim Overvad
  • Fonction : Auteur
Christina C. Dahm
Therese Haugdahl Nøst
Torkjel Manning Sandanger
  • Fonction : Auteur
Guri Skeie
Raúl Zamora-Ros
Konstantinos K. Tsilidis
Fabian Eichelmann
  • Fonction : Auteur
Matthias Bernd Schulze
Bethany R. van Guelpen
  • Fonction : Auteur
Linda Vidman
  • Fonction : Auteur
Maria José Sánchez
Pilar Amiano
  • Fonction : Auteur
Eva E. Ardanaz
Karl Smith-Byrne
  • Fonction : Auteur
Ruth C. Travis
  • Fonction : Auteur
Verena Andrea Katzke
  • Fonction : Auteur
Rudolf J. Kaaks
  • Fonction : Auteur
Jeroen W.G. Derksen
  • Fonction : Auteur
Sandra Milena Colorado-Yohar
Rosario Tumino
Bas H. Bueno-De-Mesquita
  • Fonction : Auteur
Paolo Vineis
  • Fonction : Auteur
Domenico Palli
  • Fonction : Auteur
Fabrizio Pasanisi
Anne Kirstine Eriksen
  • Fonction : Auteur
A. Marie Tjønneland
Marc J.R. Gunter
  • Fonction : Auteur

Résumé

Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
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hal-04106281 , version 1 (02-06-2023)

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Joseph A. Rothwell, Jelena Bešević, Niki L. Dimou, Marie Breeur, Neil Murphy, et al.. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. BMC Medicine, 2023, 21 (1), ⟨10.1186/s12916-023-02739-4⟩. ⟨hal-04106281⟩
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