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Article Dans Une Revue Journal of the American Ceramic Society Année : 2023

Mg2+, Sr2+, Ag+, and Cu2+ co-doped beta-tricalcium phosphate: Improved thermal stability and mechanical and biological properties

Résumé

β-tricalciumphosphate(β-TCP,β-Ca3(PO4)2)isanattractivebiomaterialforbonerepair applications. However, its sintering and mechanical properties are lim-ited by a problematic phase transition toα-TCP. Cationic doping ofβ-TCP is ableto postpone the formation ofα-TCP allowing higher sintering temperatures andbetter mechanical properties. The co-doping ofβ-TCP with Mg2+and Sr2+hasalready been studied in detail, but the addition of antibacterial cations (Ag+andCu2+) on the Mg–Srβ-TCP co-doped composition remains unexplored. Thus,two co-dopedβ-TCP compositions were realized by aqueous precipitation tech-nique without any secondary phase and compared with undopedβ-TCP: Mg–Sr(2.0–2.0 mol%) and Mg–Sr–Ag–Cu (2.0–2.0–0.1–0.1 mol%). Differential thermalanalysis and dilatometry analyses showed a slight decrease of theβ-TCP→α-TCP phase transition temperature for the Mg–Sr–Ag–Cu (2.0–2.0–0.1–0.1% mol)composition as compared to the Mg–Sr (2.0–2.0 mol%). However, both exhib-ited much higher transition temperatures than undopedβ-TCP. The additionof Ag+and Cu2+slightly reduces the grain size after sintering compared tothe Mg–Sr (2.0–2.0 mol%) and the undoped compositions. The co-doped com-positions also exhibited improved mechanical properties, specifically a higherVickers hardness and elastic modulus. Finally, cell proliferation assays showedthat the presence of dopants, even Ag+and Cu2+, does not affect the survival andproliferationofcells.Thus,theuseofMg2+,Sr2+,Ag+,andCu2+co-dopedβ-TCPcould be very promising for biomedical applications due to the improvements ofthese dopants on the thermal stability and mechanical and biological properties.
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Dates et versions

hal-04103197 , version 1 (23-05-2023)

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Nicolas Somers, Florian Jean, Marie Lasgorceix, Giovanni Urruth, Sandra Balvay, et al.. Mg2+, Sr2+, Ag+, and Cu2+ co-doped beta-tricalcium phosphate: Improved thermal stability and mechanical and biological properties. Journal of the American Ceramic Society, 2023, ⟨10.1111/jace.19093⟩. ⟨hal-04103197⟩
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