Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Nanomedicine Année : 2011

Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells

Simona Mura
Hervé Hillaireau
Julien Nicolas
Benjamin Le Droumaguet
  • Fonction : Auteur
Claire Gueutin
  • Fonction : Auteur
Sandrine Zanna
  • Fonction : Auteur
  • PersonId : 1037043
Nicolas Tsapis
Elias Fattal

Résumé

Background: Because of the described hazards related to inhalation of manufactured nanoparticles, we investigated the lung toxicity of biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles displaying various surface properties on human bronchial Calu-3 cells. Methods: Positively and negatively charged as well as neutral nanoparticles were tailored by coating their surface with chitosan, Poloxamer, or poly (vinyl alcohol), respectively. Nanoparticles were characterized in terms of size, zeta potential, and surface chemical composition, confirming modifications provided by hydrophilic polymers. Results: Although nanoparticle internalization by lung cells was clearly demonstrated, the cytotoxicity of the nanoparticles was very limited, with an absence of inflammatory response, regardless of the surface properties of the PLGA nanoparticles. Conclusion: These in vitro results highlight the safety of biodegradable PLGA nanoparticles in the bronchial epithelium and provide initial data on their potential effects and the risks associated with their use as nanomedicines.
Fichier principal
Vignette du fichier
mura-IJN2011.pdf (2.01 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04101314 , version 1 (19-05-2023)

Identifiants

Citer

Simona Mura, Hervé Hillaireau, Julien Nicolas, Benjamin Le Droumaguet, Claire Gueutin, et al.. Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells. International Journal of Nanomedicine, 2011, pp.2591-2605. ⟨10.2147/IJN.S24552⟩. ⟨hal-04101314⟩
7 Consultations
16 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More