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Article Dans Une Revue SYNLETT Année : 2022

Investigation on the stoichiometry of carbon dioxide in isotope-exchange reactions with phenylacetic acids

Résumé

The functionalization of carbon dioxide (CO$_2$) as a C1 building block has attracted enormous attention. Carboxylation reactions, in particular, are of major interest for applications in isotope labeling. Due to the inexpensive nature of CO$_2$, information about its stoichiometric use is generally unavailable in the literature. Because of the rarity and limited availability of CO$_2$ isotopomers, this parameter is of concern for applications in carbon-isotope labeling. We investigated the effects of the stoichiometry of labeled CO$_2$ on carbon isotope exchange of phenyl­acetic acids. Both thermal and photocatalytic procedures were studied, providing insight into product outcome and isotope incorporation. Preliminary results on isotope-dilution effects of carbonate bases in photocatalytic carboxylation reactions have also been obtained.

Domaines

Chimie
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Dates et versions

hal-04101303 , version 1 (22-05-2023)

Identifiants

Citer

Alex Talbot, Antoine Sallustrau, Amélie Goudet, Frédéric Taran, Davide Audisio. Investigation on the stoichiometry of carbon dioxide in isotope-exchange reactions with phenylacetic acids. SYNLETT, 2022, 33 (02), pp.171-176. ⟨10.1055/s-0040-1720447⟩. ⟨hal-04101303⟩
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