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Article Dans Une Revue Soft Matter Année : 2011

SPRAY-DRIED CHITOSAN-METAL MICROPARTICLES FOR CIPROFLOXACIN ADSORPTION: KINETIC AND EQUILIBRIUM STUDIES

Franceline Reynaud
  • Fonction : Auteur
Michel Deyme
  • Fonction : Auteur
Tibiriça Vasconcelos
  • Fonction : Auteur
Claire Gueutin
  • Fonction : Auteur
Sílvia Guterres
  • Fonction : Auteur
Adriana Pohlmann
  • Fonction : Auteur
Elias Fattal

Résumé

Chitosan, a natural polysaccharide obtained from chitin deacetylation, complexes with metal ions by coordination with the free electrons pairs of amine groups. Based on this complexation mechanism, cross-linked chitosan-metal microparticles were prepared by spray drying using iron (II or III) or zinc ions and characterized in terms of size distribution and capacity to specifically adsorb ciprofloxacin. Chitosan-Zn(II) and chitosan-Fe(III) microparticles appear to adsorb more ciprofloxacin than plain chitosan or chitosan-Fe(II) microparticles. Adsorption isotherms for CH and CH-Fe(II) microparticles can be fitted by a single logarithm model (slope 1) with one ciprofloxacin per adsorption site, whereas for CH-Fe(II) and CH-Zn(II) microparticles isotherms are rather bilogarithmic with an initial slope of 2, suggesting that a single adsorption site can bind two molecules of ciprofloxacin. In addition, the pseudo second order kinetic model fits well experimental data, proving that adsorption is mediated by a chemical reaction. CH-Fe(II) and CH-Zn(II) appear very promising for drug elimination, either from hospital waste water or from the gastrointestinal tract to prevent the emergence of antibiotic resistance.
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Dates et versions

hal-04101299 , version 1 (19-05-2023)

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Franceline Reynaud, Nicolas Tsapis, Michel Deyme, Tibiriça Vasconcelos, Claire Gueutin, et al.. SPRAY-DRIED CHITOSAN-METAL MICROPARTICLES FOR CIPROFLOXACIN ADSORPTION: KINETIC AND EQUILIBRIUM STUDIES. Soft Matter, 2011, 7 (16), pp.7304. ⟨10.1039/c1sm05509g⟩. ⟨hal-04101299⟩
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