Ore deposits in the Balkan Peninsula were intensively mined for silver and other metals in the Roman and medieval periods. Coinage mainly issued by tribal groups between the early 5 th and the end of the 3 rd century BCE provides indirect evidence that silver extraction predates the Roman conquest of the region. However, identification of centers of past metal production and reconstruction of large-scale silver fluxes can only be achieved using a comprehensive geochemical database of potential ores. Here, we present high-precision Pb-Ag-S isotope data and trace element systematics of 36 mineralizations from the Balkans. Each ore site was selected for its geological characteristics and documented or assumed historical and/or archaeological significance.