Unprecedented perspectives in the application of CinNapht fluorophores provided by a “Late-stage” functionalization strategy
Résumé
A simple and easy‐to‐implement process based on a nucleophilic aromatic substitution reaction with a wide variety of nucleophiles on a fluorinated Cin‐Napht is described. This process has the key advantage of introducing multiple functionalities at the very late stage, thus providing access to new applications including photostable and bioconjugatabable large Stokes Shift red emitting dyes, selective organelle imaging agents, or AIEE‐based wash‐free lipid droplets imaging in live cells with high signal‐to‐noise ratio. The synthesis of bench‐stable CinNapht‐F has been optimized and can be reproduced in lagre scale, making it an easy‐to‐store starting material that can be used at will to prepare new molecular imaging tools.
Domaines
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