Dynamique moléculaire de la transformation des progéniteurs myéloïdes
Molecular dynamics of myeloid progenitor transformation
Résumé
Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults. AML results from the accumulation of abnormal immature myeloid progenitors, also called blasts, that are blocked in their differentiation. AML is a very heterogeneous disease with more than a dozen of genetically distinct entities (See new AML classification from [1]). Each genetically distinct AML subgroup is generally defined by gene mutations and/or alterations related to its aggressiveness, and is associated to [...]