Deoxyribonucleic Acid and Bovine Serum Albumin Interaction with the Asymmetric Schiff Base Ligand and Its Molybdenum (VI) Complex: Multi Spectroscopic and Molecular Docking Studies - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Macromolecular Science Part B Physics Année : 2017

Deoxyribonucleic Acid and Bovine Serum Albumin Interaction with the Asymmetric Schiff Base Ligand and Its Molybdenum (VI) Complex: Multi Spectroscopic and Molecular Docking Studies

Iman Khosravi
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Mehdi Sahihi
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Maryam Dashtbani
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Hadi Amiri Rudbari
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Ghazal Borhan
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Résumé

The interaction of an asymmetric Schiff base ligand derived from allylamine and 2,3-dihydroxybenzaldehyde and its molybdenum (VI) complex with deoxyribonucleic acid (DNA) and bovine serum albumin (BSA) were studied using spectroscopic and molecular docking methods. The spectroscopic results revealed that the DNA and BSA affinity for binding the Mo(VI) complex is greater than its ligand. Furthermore, the molecular docking calculations showed that H-bond, hydrophobic, π-π and π-cation interactions had the dominant roles in the stability of the compound-BSA complexes. The DNA interaction results suggested that the compounds interacted with DNA by the groove binding mechanism.
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hal-04086639 , version 1 (02-05-2023)

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Iman Khosravi, Mehdi Sahihi, Maryam Dashtbani, Hadi Amiri Rudbari, Ghazal Borhan. Deoxyribonucleic Acid and Bovine Serum Albumin Interaction with the Asymmetric Schiff Base Ligand and Its Molybdenum (VI) Complex: Multi Spectroscopic and Molecular Docking Studies. Journal of Macromolecular Science Part B Physics, 2017, 56 (9), pp.655-669. ⟨10.1080/00222348.2017.1361265⟩. ⟨hal-04086639⟩
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