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Article Dans Une Revue Journal of Cystic Fibrosis Année : 2023

Exploration of the relationship between cumulative exposure to tobramycin and ototoxicity in patients with cystic fibrosis

Résumé

Background Aminoglycosides (AGs), such as tobramycin, are essential antibiotics in the management of pulmonary infections in patients with cystic fibrosis (CF). They induce ototoxicity without the relationship being clearly described in the literature. Our aim is to propose a mathematical and statistical model describing the relationship between the estimated cumulative exposure (Area Under the Curve, AUC) to tobramycin and ototoxicity with audiogram interpretation in young patients with CF. Methods Cumulative AUCs were estimated for each course of tobramycin, for the 106 individuals with CF (between 4 and 22 years of age) enrolled in this retrospective study (35 who had received IV tobramycin, 71 controls). Mean hearing loss was calculated for each audiogram and a statistical model was developed to predict hearing loss. Results The model confirms a significant relationship between cumulative tobramycin exposure and changes in hearing acuity:
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Dates et versions

hal-04086358 , version 1 (04-05-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Justine Madaule, Félix Valenzuela, Marie Mittaine, Yohan Gallois, Blandine Baladi, et al.. Exploration of the relationship between cumulative exposure to tobramycin and ototoxicity in patients with cystic fibrosis. Journal of Cystic Fibrosis, 2023, pp.1-5. ⟨10.1016/j.jcf.2023.04.002⟩. ⟨hal-04086358⟩
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