Synthesis of novel naphtho[1,2-e][1,3]oxazines bearing an arylsulfonamide moiety and their anticancer and antifungal activity evaluations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Arabian Journal of Chemistry Année : 2020

Synthesis of novel naphtho[1,2-e][1,3]oxazines bearing an arylsulfonamide moiety and their anticancer and antifungal activity evaluations

Résumé

A series of novel naphtho[1,2-e][1,3]oxazines bearing arylsulfonamide moiety have been synthesized via a one-pot approach and in a green reaction medium. These new naphtho[1,2e][1,3]oxazine derivatives have been characterized by their 1 H NMR, 13 C NMR and the X-ray single crystallography method for compound 7a. All the newly synthesized compounds were examined for their in vitro anticancer activity against breast (MCF-7), colon (HCT116), and B-CLL (Waco3-CD5) cancers. Some of these compounds such as 7j and 7l showed remarkable activities against MCF-7 (breast) and HCT116 (colon) cancers with comparable IC50 (The half maximal inhibitory concentration) values as that of known drugs such as 5-fluorouracil (5-FU). In vitro antimicrobial activities of all compounds were also evaluated against five human pathogenic fungi strains and two bacteria (one gram positive and one gram negative). The best MICs (Minimum Inhibitory Concentrations) were found against the C. albicans.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
Synthesis of novel naphtho.pdf (644.41 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04084155 , version 1 (27-04-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Seyed Gholamhossein Mansouri, Hassan Zali-Boeini, Kamiar Zomorodian, Bahman Khalvati, Razie Helali Pargali, et al.. Synthesis of novel naphtho[1,2-e][1,3]oxazines bearing an arylsulfonamide moiety and their anticancer and antifungal activity evaluations. Arabian Journal of Chemistry, 2020, 13 (1), pp.1271-1282. ⟨10.1016/j.arabjc.2017.10.009⟩. ⟨hal-04084155⟩
4 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More