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Article Dans Une Revue (Article De Synthèse) Journal of Separation Science Année : 2023

Ligand fishing as a tool to screen natural products with anticancer potential

Résumé

Cancer is the second leading cause of death in the world and its incidence is expected to increase with the aging of the world's population and globalization of risk factors. Natural products and their derivatives have provided a significant number of approved anticancer drugs and the development of robust and selective screening assays for the identification of lead anticancer natural products are essential in the challenge of developing personalized targeted therapies tailored to the genetic and molecular characteristics of tumors. To this end, a ligand fishing assay is a remarkable tool to rapidly and rigorously screen complex matrices, such as plant extracts, for the isolation and identification of specific ligands that bind to relevant pharmacological targets. In this paper, we review the application of ligand fishing with cancer-related targets to screen natural product extracts for the isolation and identification of selective ligands. We provide critical analysis of the system configurations, targets, and key phytochemical classes related to the field of anticancer research. Based on the data collected, ligand fishing emerges as a robust and powerful screening system for the rapid discovery of new anticancer drugs from natural resources. It is currently an underexplored strategy according to its considerable potential.
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Dates et versions

hal-04082833 , version 1 (13-07-2023)

Identifiants

Citer

Luiz Antonio Miranda de Souza Duarte-Filho, Pamella Christina Ortega de Oliveira, Cíntia Emi Yanaguibashi Leal, Marcela Cristina de Moraes, Laurent Picot. Ligand fishing as a tool to screen natural products with anticancer potential. Journal of Separation Science, 2023, 46 (12), pp.2200964. ⟨10.1002/jssc.202200964⟩. ⟨hal-04082833⟩

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