Brain Structure Ages - A new biomarker for multi-disease classification - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Human Brain Mapping Année : 2024

Brain Structure Ages - A new biomarker for multi-disease classification

Résumé

Age is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging, predicted brain age is widely used to analyze different diseases. However, using only the brain age gap information (i.e., the difference between the chronological age and the estimated age) can be not enough informative for disease classification problems. In this paper, we propose to extend the notion of global brain age by estimating brain structure ages using structural magnetic resonance imaging. To this end, an ensemble of deep learning models is first used to estimate a 3D aging map (i.e., voxel-wise age estimation). Then, a 3D segmentation mask is used to obtain the final brain structure ages. This biomarker can be used in several situations. First, it enables to accurately estimate the brain age for the purpose of anomaly detection at the population level. In this situation, our approach outperforms several state-of-the-art methods. Second, brain structure ages can be used to compute the deviation from the normal aging process of each brain structure. This feature can be used in a multi-disease classification task for an accurate differential diagnosis at the subject level. Finally, the brain structure age deviations of individuals can be visualized, providing some insights about brain abnormality and helping clinicians in real medical contexts.
Fichier principal
Vignette du fichier
Age_prediction_Journal_HBM_Style_v3_main.pdf (1.02 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04080401 , version 1 (24-04-2023)
hal-04080401 , version 2 (10-12-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Huy-Dung Nguyen, Michaël Clément, Boris Mansencal, Pierrick Coupé. Brain Structure Ages - A new biomarker for multi-disease classification. Human Brain Mapping, 2024, 45 (1), ⟨10.1002/hbm.26558⟩. ⟨hal-04080401v2⟩

Collections

CNRS ANR
51 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More