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Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Receptors and Cofactors That Contribute to SARS-CoV-2 Entry: Can Skin Be an Alternative Route of Entry?

Manon Barthe
  • Fonction : Auteur
Leslie Hertereau
  • Fonction : Auteur
Noura Lamghari
  • Fonction : Auteur
Hanan Osman-Ponchet
  • Fonction : Auteur

Résumé

To prevent the spread of SARS-CoV-2, all routes of entry of the virus into the host must be mapped. The skin is in contact with the external environment and thus may be an alternative route of entry to transmission via the upper respiratory tract. SARS-CoV-2 cell entry is primarily dependent on ACE2 and the proteases TMPRSS2 or cathepsin L but other cofactors and attachment receptors have been identified that may play a more important role in specific tissues such as the skin. The continued emergence of new variants may also alter the tropism of the virus. In this review, we summarize current knowledge on these receptors and cofactors, their expression profile, factors modulating their expression and their role in facilitating SARS-CoV-2 infection. We discuss their expression in the skin and their possible involvement in percutaneous infection since the presence of the virus has been detected in the skin.
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hal-04077172 , version 1 (21-04-2023)

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Manon Barthe, Leslie Hertereau, Noura Lamghari, Hanan Osman-Ponchet, Veronique M Braud. Receptors and Cofactors That Contribute to SARS-CoV-2 Entry: Can Skin Be an Alternative Route of Entry?. International Journal of Molecular Sciences, 2023, 24 (7), pp.6253. ⟨10.3390/ijms24076253⟩. ⟨hal-04077172⟩
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