We consider the mass-supercritical, defocusing, nonlinear Schrödinger equation. We prove loss of regularity in arbitrarily short times for regularized initial data belonging to a dense set of any fixed Sobolev space for which the nonlinearity is supercritical. The proof relies on the construction of initial data as a superposition of disjoint bubbles at different scales. We get an approximate solution with a time of existence bounded from below, provided by the compressible Euler equation, which enjoys zero speed of propagation. Introducing suitable renormalized modulated energy functionals, we prove spatially localized estimates which make it possible to obtain the loss of regularity.