Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
2 ITX - ITX - unité de recherche de l'institut du thorax
3 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
4 UvA - Universiteit van Amsterdam = University of Amsterdam
5 Hôpital Haut-Lévêque [CHU Bordeaux]
6 IHU Liryc - Institut de rythmologie et modélisation cardiaque [Pessac]
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
8 UZ Brussel - Universitair Ziekenhuis Brussel = University Hospital of Brussels
9 UNITO - Università degli studi di Torino = University of Turin
10 UB - Universitat de Barcelona
11 Tel Aviv Sourasky Medical Center [Tel Aviv]
12 Catholic University of Korea
13 NTU - College of Medicine [National Taiwan University]
14 TMDU - Tokyo Medical and Dental University [Japan]
15 N3C - Suita - National Cerebral and Cardiovascular Center [Osaka, Japon]
16 BIDMC - Beth Israel Deaconess Medical Center [Boston]
17 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
18 Xiamen University
19 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
20 UPD7 - Université Paris Diderot - Paris 7
21 St George's, University of London
22 IRCCS Pavia - ICS Maugeri - Istituti Clinici Scientifici Maugeri [Pavia]
23 UdG - Universitat de Girona = University of Girona
24 ULB - Université libre de Bruxelles = Free University of Brussels
25 Quebec Heart and Lung Institute
26 Ospedale Policlinico Casilino - Policlinico Casilino
27 UCPH - Københavns Universitet = University of Copenhagen = Université de Copenhague
28 Kansai University
29 MHH - Medizinische Hochschule Hannover = Hannover Medical School
30 CP - Clinica Pederzoli [Peschiera del Garda, Italy]
31 Unipd - Università degli Studi di Padova = University of Padua
32 LIMR - Lankenau Institute for Medical Research [Wynnewood]
33 University of Ulsan
- Fonction : Auteur
- PersonId : 1025202
- ORCID : 0000-0002-6961-2131
- IdRef : 157411036
- Fonction : Auteur
- PersonId : 862692
- ORCID : 0000-0001-7368-4528
- Fonction : Auteur
- PersonId : 947953
- ORCID : 0000-0002-5492-8619
- IdRef : 088101886
Résumé
Background: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs).Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE.Methods: The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27-84 years (mean age 42.5 ± 14.1 years) at the time of AE occurrence.Results: After excluding pediatric patients, it was found that females were older than males (49.5 ± 14.4 years vs 43 ± 12.7 years, respectively; P = .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was ≈9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (≈65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007).Conclusion: This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than do males. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity.