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Article Dans Une Revue eLife Année : 2019

Offline impact of transcranial focused ultrasound on cortical activation in primates

Charlotte Constans
Daria Ea Jensen
  • Fonction : Auteur
Bashir Ahmed
  • Fonction : Auteur
Rogier Mars
  • Fonction : Auteur
Pierre Pouget
Jean-François Aubry
Jerome Sallet

Résumé

To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver on its full potential for research and therapy, ultrasound protocols are required that induce longer-lasting ‘offline’ changes. Here, we present a TUS protocol that modulates brain activation in macaques for more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity in brain areas reflects activity in interconnected regions but TUS caused stimulated areas to interact more selectively with the rest of the brain. In a within-subject design, we observe regionally specific TUS effects for two medial frontal brain regions – supplementary motor area and frontal polar cortex. Independently of these site-specific effects, TUS also induced signal changes in the meningeal compartment. TUS effects were temporary and not associated with microstructural changes.

Dates et versions

hal-04073656 , version 1 (18-04-2023)

Identifiants

Citer

Lennart Verhagen, Cécile Gallea, Davide Folloni, Charlotte Constans, Daria Ea Jensen, et al.. Offline impact of transcranial focused ultrasound on cortical activation in primates. eLife, 2019, 8, ⟨10.7554/eLife.40541⟩. ⟨hal-04073656⟩
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