Accelerated Surgery Versus Standard Care in Hip Fracture (HIP ATTACK-1): A Kidney Substudy of a Randomized Clinical Trial
Flavia K Borges
(1)
,
Pj Devereaux
(1)
,
Meaghan Cuerden
(2)
,
Jessica M Sontrop
(2)
,
Mohit Bhandari
(1)
,
Ernesto Guerra-Farfan
(3)
,
Ameen Patel
(1)
,
Alben Sigamani
(4)
,
Masood Umer
(5)
,
John Neary
(1)
,
Maria Tiboni
(1)
,
Vikas Tandon
(1)
,
Mmampapatla Thomas Ramokgopa
(6)
,
Parag Sancheti
(7)
,
Abdel-Rahman Lawendy
(8)
,
Mariano Balaguer-Castro
(9)
,
Richard Jenkinson
(10)
,
Pawel Sleczka
(11)
,
Aamer Nabi Nur
(12)
,
Gavin Ca Wood
(13)
,
Robert J Feibel
(14)
,
John Stephen Mcmahon
(15)
,
Bruce M Biccard
(16)
,
Alessandro Ortalda
(17)
,
Wojciech Szczeklik
(18)
,
Chew Yin Wang
(19)
,
Jordi Tomas-Hernandez
(3)
,
Jessica Vincent
(20)
,
Valerie Harvey
(20)
,
Shirley Pettit
(20)
,
Kumar Balasubramanian
(20)
,
Gerard Slobogean
(21)
,
Amit X Garg
(1)
,
Anthony Viste
(22)
1
McMaster University [Hamilton, Ontario]
2 LHSC - London Health Sciences Center
3 Vall d'Hebron University Hospital [Barcelona]
4 Clinical Research, Narayana Hrudayalaya Limited
5 The Aga Khan University
6 WITS - University of the Witwatersrand [Johannesburg]
7 Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation
8 UWO - University of Western Ontario
9 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
10 University of Toronto
11 Orthopaedic Department, SPZOZ
12 Shifa International Hospital
13 Queen's University [Kingston, Canada]
14 University of Ottawa [Ottawa]
15 Markham Stouffville Hospital
16 University of Cape Town
17 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
18 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
19 Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie]
20 Population Health Research Institute
21 University of Maryland School of Medicine
22 LBMC UMR T9406 - Laboratoire de Biomécanique et Mécanique des Chocs
2 LHSC - London Health Sciences Center
3 Vall d'Hebron University Hospital [Barcelona]
4 Clinical Research, Narayana Hrudayalaya Limited
5 The Aga Khan University
6 WITS - University of the Witwatersrand [Johannesburg]
7 Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation
8 UWO - University of Western Ontario
9 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
10 University of Toronto
11 Orthopaedic Department, SPZOZ
12 Shifa International Hospital
13 Queen's University [Kingston, Canada]
14 University of Ottawa [Ottawa]
15 Markham Stouffville Hospital
16 University of Cape Town
17 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
18 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
19 Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie]
20 Population Health Research Institute
21 University of Maryland School of Medicine
22 LBMC UMR T9406 - Laboratoire de Biomécanique et Mécanique des Chocs
Résumé
In summary, the risk of perioperative AKI was not significantly different in patients allocated to accelerated surgery versus standard care for hip fracture. AKI occurred nearly twice as often in patients with versus without CKD (21% vs 11%); however, regardless of CKD status, the risk of AKI was not significantly lower with accelerated surgery versus standard care.