Sec22b is a critical and non-redundant regulator of plasma cell maintenance
Résumé
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In absence of Sec22b, plasma cells were hardly detectable and serum antibody titres were dramatically reduced. Accordingly, Sec22b deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and non-redundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.
Domaines
Sciences du Vivant [q-bio]
Fichier principal
Main text Bonaud HAL.pdf (410.67 Ko)
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Figures Bonaud HAL_compressed.pdf (874.88 Ko)
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Supplementary data HAL_compressed.pdf (980.7 Ko)
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