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Article Dans Une Revue Journal of Hazardous Materials Année : 2022

Assessment of the occurrence of 455 pharmaceutical compounds in sludge according to their physical and chemical properties: A review

Résumé

Sludge agronomical reuse is of major interest due to the beneficial contribution of nutrients. However, it implies the introduction of unregulated pharmaceuticals into amended-soils and creates a controversial issue about sludge management. To limit their dissemination, it is essential to identify the compounds of interest and understand their attenuation mechanisms through the sludge processes. This paper summarizes the knowledge on 455 investigated pharmaceuticals among therapeutical categories in amendable sludge matrices. It contributes to enlarging the list of commonly quantified compounds to 305 residues including additional compounds compared to previous reviews. It highlights that sorption appears as the main mechanism controlling the occurrence of pharmaceuticals in sludge matrices and shows the considerable residual levels of pharmaceuticals reaching several mg/kg in dry weight. Antibiotics, stimulants, and antidepressants show the highest concentrations up to 232 mg/kg, while diuretics, anti-anxieties or anticoagulants present the lowest concentrations reaching up to 686 µg/kg. Collected data show the increase in investigated compounds as antifungals or antihistamines, and underline emerging categories like antidiabetics, antivirals, or antiarrhythmics. The in-depth analysis of the substantial database guides onto the pharmaceuticals that are the most likely to occur in these amendable matrices to assist future research.
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Dates et versions

hal-04063153 , version 1 (08-04-2023)

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Anastasia Sellier, Somar Khaska, Corinne Le Gal La Salle. Assessment of the occurrence of 455 pharmaceutical compounds in sludge according to their physical and chemical properties: A review. Journal of Hazardous Materials, 2022, 426, pp.128104. ⟨10.1016/j.jhazmat.2021.128104⟩. ⟨hal-04063153⟩

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