Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cardiovascular Research Année : 2023

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

1 Amsterdam UMC - Amsterdam University Medical Center
2 UMCU - University Medical Center [Utrecht]
3 UCL - University College of London [London]
4 Institute for Molecular and Translational Therapeutic Strategies - IMTTS [Hannover, Germany]
5 UCL - Université Catholique de Louvain = Catholic University of Louvain
6 IREC - Institut de Recherche Expérimentale et Clinique
7 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
8 DZHK - German Center for Cardiovascular Research
9 University of Aberdeen
10 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
11 Erasmus MC - Erasmus University Medical Center [Rotterdam]
12 University of Birmingham [Birmingham]
13 FMUP - Faculdade de Medicina da Universidade do Porto
14 Semmelweis University [Budapest]
15 Università degli studi di Trieste = University of Trieste
16 UC - University of Coimbra [Portugal]
17 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
18 Medizinische Universität Wien = Medical University of Vienna
19 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
20 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
21 The Netherlands Heart Institute
22 MUMC - Maastricht University Medical Centre
23 Cardiovascular surgery
24 MHH - Medizinische Hochschule Hannover = Hannover Medical School
25 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
26 HEGP - Hôpital Européen Georges Pompidou [APHP]
27 CIC 1418 - CIC - HEGP
28 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
29 Universiteit Utrecht / Utrecht University [Utrecht]
30 University of Cape Town
31 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
32 CARIM - Cardiovascular Research Institute Maastricht
33 University of Pisa - Università di Pisa
34 The University of Texas Medical School at Houston
35 Karolinska Institutet [Stockholm]
36 King‘s College London
37 UMCG - University Medical Center Groningen [Groningen]
38 University of Naples Federico II = Università degli studi di Napoli Federico II
39 Centro Cardiologico Monzino [Milano]
40 ERN GUARD-Heart - European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart
41 JLU - Justus-Liebig-Universität Gießen = Justus Liebig University
Jeroen Bakkers
Ilze Bot
Steven Chamuleau
  • Fonction : Auteur
Michele Ciccarelli
Dana Dawson
Sean M Davidson
Larissa Fabritz
Henrique Girao
Nazha Hamdani
Andres Hilfiker
Sandrine Lecour
Tim Leiner
Lars Maegdefessel
Manuel Mayr
Robert Passier
Maurizio Pesce
Bodo Rosenhahn
  • Fonction : Auteur
Ulrich Schotten
Frank van Steenbeek
  • Fonction : Auteur
Sabine Steffens
Cesare M Terracciano
  • Fonction : Auteur
Carlo Gabriele Tocchetti
Patricia Vlasman
Kak Khee Yeung
Serena Zacchigna
Dayenne Zwaagman
  • Fonction : Auteur
Thomas Thum

Résumé

Abstract Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies, all of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task, in particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and comorbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational ‘valley of death’, which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models do not represent a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on an organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and state-of-the-art animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction, and refinement (3R) as a guiding concept.
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hal-04052531 , version 1 (30-03-2023)

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Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, et al.. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 2023, 118 (15), pp.3016-3051. ⟨10.1093/cvr/cvab370⟩. ⟨hal-04052531⟩

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