Zinc-Catalyzed Hydrocyanation of Ynamides and Photoisomerization, a General and Selective Access to E and Z Trisubstituted Alpha-Enamidonitriles
Résumé
The fully regio and stereoselective Zn-catalyzed hydrocyanation of ynamides is reported and represents a general access to various trisubstituted E- alpha-enamidonitriles. The catalyst-free photoisomerization selectively yields the energetically comparable Z stereoisomer. Finally, the synthetic potential of these new !enamidonitriles was evaluated through the synthesis of original heterocycles.
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