Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries - HAL Accéder directement au contenu
Article dans une revue Annals of the Rheumatic Diseases Année : 2023

Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries

Pedro M Machado
Martin Schäfer
Satveer K Mahil
  • Fonction : Auteur
Jean Liew
  • Fonction : Auteur
Nick Dand
  • Fonction : Auteur
Alexander Pfeil
Anja Strangfeld
Anne Constanze Regierer
Carla Gimena Alonso
  • Fonction : Auteur
Carla G S Saad
  • Fonction : Auteur
Christopher E M Griffiths
  • Fonction : Auteur
Claudia Lomater
  • Fonction : Auteur
Corinne Miceli-Richard
Daniel Wendling
Deshire Alpizar Rodriguez
Dieter Wiek
  • Fonction : Auteur
Elsa F Mateus
Emily Sirotich
Enrique R Soriano
Francinne Machado Ribeiro
Felipe Omura
  • Fonction : Auteur
Frederico Rajão Martins
Helena Santos
  • Fonction : Auteur
Jonathan Dau
  • Fonction : Auteur
Jonathan N Barker
  • Fonction : Auteur
Jonathan Hausmann
Kimme L Hyrich
Lianne Gensler
  • Fonction : Auteur
Ligia Silva
  • Fonction : Auteur
Lindsay Jacobsohn
  • Fonction : Auteur
Loreto Carmona
Marcelo M Pinheiro
Marcos David Zelaya
  • Fonction : Auteur
Mark Yates
Maureen Dubreuil
  • Fonction : Auteur
Monique Gore-Massy
  • Fonction : Auteur
Nicoletta Romeo
  • Fonction : Auteur
Nigil Haroon
  • Fonction : Auteur
Paul Sufka
  • Fonction : Auteur
Rebecca Grainger
  • Fonction : Auteur
Rebecca Hasseli
Saskia Lawson-Tovey
Suleman Bhana
  • Fonction : Auteur
Thao Pham
Tor Olofsson
Wilson Bautista-Molano
  • Fonction : Auteur
Zachary S Wallace
  • Fonction : Auteur
Zenas Z N Yiu
  • Fonction : Auteur
Jinoos Yazdany
  • Fonction : Auteur
Philip C Robinson
Catherine H Smith
  • Fonction : Auteur

Résumé

Objectives To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. Results Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/ high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. Conclusion Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/ IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.
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Dates et versions

hal-04051644, version 1 (30-03-2023)

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Pedro M Machado, Martin Schäfer, Satveer K Mahil, Jean Liew, Laure Gossec, et al.. Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries. Annals of the Rheumatic Diseases, 2023, pp.ard-2022-223499. ⟨10.1136/ard-2022-223499⟩. ⟨hal-04051644⟩
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