Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries
Pedro M Machado
,
Martin Schäfer
,
Satveer K Mahil
,
Jean Liew
,
Laure Gossec
(1)
,
Nick Dand
,
Alexander Pfeil
,
Anja Strangfeld
,
Anne Constanze Regierer
,
Bruno Fautrel
(1)
,
Carla Gimena Alonso
,
Carla G S Saad
,
Christopher E M Griffiths
,
Claudia Lomater
,
Corinne Miceli-Richard
,
Daniel Wendling
,
Deshire Alpizar Rodriguez
,
Dieter Wiek
,
Elsa F Mateus
,
Emily Sirotich
,
Enrique R Soriano
,
Francinne Machado Ribeiro
,
Felipe Omura
,
Frederico Rajão Martins
,
Helena Santos
,
Jonathan Dau
,
Jonathan N Barker
,
Jonathan Hausmann
,
Kimme L Hyrich
,
Lianne Gensler
,
Ligia Silva
,
Lindsay Jacobsohn
,
Loreto Carmona
,
Marcelo M Pinheiro
,
Marcos David Zelaya
,
María de los Ángeles Severina
,
Mark Yates
,
Maureen Dubreuil
,
Monique Gore-Massy
,
Nicoletta Romeo
,
Nigil Haroon
,
Paul Sufka
,
Rebecca Grainger
,
Rebecca Hasseli
,
Saskia Lawson-Tovey
,
Suleman Bhana
,
Thao Pham
,
Tor Olofsson
,
Wilson Bautista-Molano
,
Zachary S Wallace
,
Zenas Z N Yiu
,
Jinoos Yazdany
,
Philip C Robinson
,
Catherine H Smith
Pedro M Machado
- Fonction : Auteur
- PersonId : 770481
- ORCID : 0000-0002-8411-7972
Martin Schäfer
- Fonction : Auteur
- PersonId : 1220105
- ORCID : 0000-0001-6487-3634
Satveer K Mahil
- Fonction : Auteur
Jean Liew
- Fonction : Auteur
Laure Gossec
- Fonction : Auteur
- PersonId : 984216
- IdHAL : lauregossec
- ORCID : 0000-0002-4528-310X
- IdRef : 061096504
Nick Dand
- Fonction : Auteur
Alexander Pfeil
- Fonction : Auteur
- PersonId : 1242854
- ORCID : 0000-0002-2709-6685
Anja Strangfeld
- Fonction : Auteur
- PersonId : 790954
- ORCID : 0000-0002-6233-022X
Anne Constanze Regierer
- Fonction : Auteur
- PersonId : 1242855
- ORCID : 0000-0003-2456-4049
Bruno Fautrel
- Fonction : Auteur
- PersonId : 759312
- ORCID : 0000-0001-8845-4274
Carla Gimena Alonso
- Fonction : Auteur
Carla G S Saad
- Fonction : Auteur
Christopher E M Griffiths
- Fonction : Auteur
Claudia Lomater
- Fonction : Auteur
Corinne Miceli-Richard
- Fonction : Auteur
- PersonId : 1242856
- ORCID : 0000-0002-3009-3637
Daniel Wendling
- Fonction : Auteur
- PersonId : 759310
- ORCID : 0000-0002-4687-5780
Deshire Alpizar Rodriguez
- Fonction : Auteur
- PersonId : 1228482
- ORCID : 0000-0002-6930-0517
Dieter Wiek
- Fonction : Auteur
Elsa F Mateus
- Fonction : Auteur
- PersonId : 1153640
- ORCID : 0000-0003-0059-2141
Emily Sirotich
- Fonction : Auteur
- PersonId : 1220110
- ORCID : 0000-0002-7087-8543
Enrique R Soriano
- Fonction : Auteur
- PersonId : 1242857
- ORCID : 0000-0003-3143-1084
Francinne Machado Ribeiro
- Fonction : Auteur
- PersonId : 1242858
- ORCID : 0000-0003-0038-983X
Felipe Omura
- Fonction : Auteur
Frederico Rajão Martins
- Fonction : Auteur
- PersonId : 1242859
- ORCID : 0000-0002-9742-2677
Helena Santos
- Fonction : Auteur
Jonathan Dau
- Fonction : Auteur
Jonathan N Barker
- Fonction : Auteur
Jonathan Hausmann
- Fonction : Auteur
- PersonId : 1220111
- ORCID : 0000-0003-0786-8788
Kimme L Hyrich
- Fonction : Auteur
- PersonId : 815703
- ORCID : 0000-0001-8242-9262
Lianne Gensler
- Fonction : Auteur
Ligia Silva
- Fonction : Auteur
Lindsay Jacobsohn
- Fonction : Auteur
Loreto Carmona
- Fonction : Auteur
- PersonId : 768595
- ORCID : 0000-0002-4401-2551
Marcelo M Pinheiro
- Fonction : Auteur
- PersonId : 1242860
- ORCID : 0000-0002-1896-8322
Marcos David Zelaya
- Fonction : Auteur
María de los Ángeles Severina
- Fonction : Auteur
Mark Yates
- Fonction : Auteur
- PersonId : 1242861
- ORCID : 0000-0001-5449-5211
Maureen Dubreuil
- Fonction : Auteur
Monique Gore-Massy
- Fonction : Auteur
Nicoletta Romeo
- Fonction : Auteur
Nigil Haroon
- Fonction : Auteur
Paul Sufka
- Fonction : Auteur
Rebecca Grainger
- Fonction : Auteur
Rebecca Hasseli
- Fonction : Auteur
- PersonId : 1220107
- ORCID : 0000-0002-2982-8253
Saskia Lawson-Tovey
- Fonction : Auteur
- PersonId : 1153638
- ORCID : 0000-0002-8611-162X
Suleman Bhana
- Fonction : Auteur
Thao Pham
- Fonction : Auteur
- PersonId : 1242862
- ORCID : 0000-0002-5978-0983
Tor Olofsson
- Fonction : Auteur
- PersonId : 1242863
- ORCID : 0000-0002-9919-4487
Wilson Bautista-Molano
- Fonction : Auteur
Zachary S Wallace
- Fonction : Auteur
Zenas Z N Yiu
- Fonction : Auteur
Jinoos Yazdany
- Fonction : Auteur
Philip C Robinson
- Fonction : Auteur
- PersonId : 1220112
- ORCID : 0000-0002-3156-3418
Catherine H Smith
- Fonction : Auteur
Résumé
Objectives To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. Results Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/ high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. Conclusion Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/ IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries
|
Résumé |
en
Objectives To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. Results Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/ high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. Conclusion Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/ IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.
|
Auteur(s) |
Pedro M Machado
, Martin Schäfer
, Satveer K Mahil
, Jean Liew
, Laure Gossec
1
, Nick Dand
, Alexander Pfeil
, Anja Strangfeld
, Anne Constanze Regierer
, Bruno Fautrel
1
, Carla Gimena Alonso
, Carla G S Saad
, Christopher E M Griffiths
, Claudia Lomater
, Corinne Miceli-Richard
, Daniel Wendling
, Deshire Alpizar Rodriguez
, Dieter Wiek
, Elsa F Mateus
, Emily Sirotich
, Enrique R Soriano
, Francinne Machado Ribeiro
, Felipe Omura
, Frederico Rajão Martins
, Helena Santos
, Jonathan Dau
, Jonathan N Barker
, Jonathan Hausmann
, Kimme L Hyrich
, Lianne Gensler
, Ligia Silva
, Lindsay Jacobsohn
, Loreto Carmona
, Marcelo M Pinheiro
, Marcos David Zelaya
, María de los Ángeles Severina
, Mark Yates
, Maureen Dubreuil
, Monique Gore-Massy
, Nicoletta Romeo
, Nigil Haroon
, Paul Sufka
, Rebecca Grainger
, Rebecca Hasseli
, Saskia Lawson-Tovey
, Suleman Bhana
, Thao Pham
, Tor Olofsson
, Wilson Bautista-Molano
, Zachary S Wallace
, Zenas Z N Yiu
, Jinoos Yazdany
, Philip C Robinson
, Catherine H Smith
1
PEPITES -
Pharmacoépidémiologie et évaluation des soins [iPLesp]
( 1082239 )
- 27 rue Chaligny, 75012 Paris - France
- France
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Langue du document |
Anglais
|
Nom de la revue |
|
Date de publication |
2023-02-14
|
Page/Identifiant |
ard-2022-223499
|
Domaine(s) |
|
DOI | 10.1136/ard-2022-223499 |
Origine :
Publication financée par une institution
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