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Article Dans Une Revue Scientific Reports Année : 2023

Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)

Manon Desclides
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Valéry Ozenne
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Pierre Bour
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Thibaut Faller
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Guillaume Machinet
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Christophe Pierre
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Stéphane Chemouny
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Résumé

Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature-time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT.
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Dates et versions

hal-04045075 , version 1 (24-03-2023)

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Manon Desclides, Valéry Ozenne, Pierre Bour, Thibaut Faller, Guillaume Machinet, et al.. Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT). Scientific Reports, 2023, 13 (1), pp.3279. ⟨10.1038/s41598-023-29818-z⟩. ⟨hal-04045075⟩

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