This special issue aims at providing optimal, secure, and context-aware e-health systems with the best quality of services (QoS) and user experience (QoE). Applications and services are implemented in wireless environments and architecture with the use of IoT (Internet of Things), big data analysis, and a strong heterogeneity of access technologies, sensors, terminals, user needs analyzers, and services (data, content, live streams, or complex network services). Emerging e-health services and applications can involve the use of “heavy” content such as multimedia content and streams (e.g., 3D-TV, media conferencing, remote live diagnostics) using conventional e-health devices or terminals such as smart TV sets, home boxes, smartphones, tablets, and new things. The main topics of e-HPWAS are related to e-health care and safety services provided for patients, the elderly, and dependent persons. These services are generally built using different communication technologies for different profiles of people in different contexts and places (e.g., in health institutions, at home, in cities). The provided services should, ideally, be accessible anytime, anywhere, and using any kind of device or platform.