Spray flame synthesis is a promising system for the production of nanoparticles with specific properties. For this, an accurate comprehension of the effect of turbulent flames on nanoparticle production is needed since the particle characteristics are governed by the local conditions that the particles experience along their trajectory. In this context, Direct Numerical Simulation (DNS) of academic configurations is of interest to investigate turbulence, flame and nanoparticle interactions, and to compare the performance of different models. In this work, the classical case of a flame interacting with homogeneous isotropic turbulence (HIT) is extended to TiO 2 nanoparticle flame synthesis. For this, the interaction between HIT and an H 2 /air non-premixed flame, doped with titanium isopropoxide (TTIP) precursor, is considered. This configuration will allow the characterization of the evolution of particle size and morphology as functions of various simulation parameters, such as the precursor concentration and the Reynolds number of the turbulence. The role of mixing, formation, sintering, coagulation and thermophoresis can be also investigated to provide directions towards possible optimization of the aerosol systems.