Salivary lipid mediators: Key indexes of inflammation regulation in heart failure disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Free Radical Biology and Medicine Année : 2023

Salivary lipid mediators: Key indexes of inflammation regulation in heart failure disease

Résumé

Cardiovascular diseases (CVDs) are the leading cause of premature death and disability in humans and their incidence continues to increase. Oxidative stress and inflammation have been recognized as key pathophysiological factors in cardiovascular events. The targeted modulation of the endogenous mechanisms of inflammation, rather than its simple suppression, will become key in treating chronic inflammatory diseases. A comprehensive characterization of the signalling molecules involved in inflammation, such as endogenous lipid mediators, is thus needed. Here, we propose a powerful MS-based platform for the simultaneous quantitation of sixty salivary lipid mediators in CVD samples. Saliva, which represents a non-invasive and painless alternative to blood, was collected from patients suffering from acute and chronic heart failure (AHF and CHF, respectively), obesity and hypertension. Of all the patients, those with AHF and hypertension showed higher levels of isoprostanoids, which are key indexes of oxidant insult. Compared to the obese population, AHF patients showed lower levels (p < 0.02) of antioxidant omega-3 fatty acids, in line with the "malnutrition-inflammation complex syndrome" typical of HF patients. At hospital admission, AHF patients showed significantly higher levels (p < 0.001) of omega-3 DPA and lower levels (p < 0.04) of lipoxin B4 than CHF patients, suggesting a lipid rearrangement typical of the failing heart during acute decompensation. If confirmed, our results highlight the potential use of lipid mediators as predictive markers of re-acutisation episodes, thus providing opportunities for preventive intervention and a reduction in hospitalizations.
Fichier principal
Vignette du fichier
Biagini et al._revised version_UNMARKED.pdf (760.53 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04040586 , version 1 (23-03-2023)

Identifiants

Citer

Denise Biagini, Silvia Ghimenti, Alessio Lenzi, Andrea Bonini, Federico Vivaldi, et al.. Salivary lipid mediators: Key indexes of inflammation regulation in heart failure disease. Free Radical Biology and Medicine, 2023, 201, pp.55-65. ⟨10.1016/j.freeradbiomed.2023.03.015⟩. ⟨hal-04040586⟩
27 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More