Activated mTOR and PKR Kinases in Lymphocytes Correlate with Memory and Cognitive Decline in Alzheimer’s Disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Dementia and Geriatric Cognitive Disorders Année : 2006

Activated mTOR and PKR Kinases in Lymphocytes Correlate with Memory and Cognitive Decline in Alzheimer’s Disease

Résumé

Background: The control of translation, involving the kinases mTOR (mammalian target of rapamycin) and PKR (double-stranded RNA-dependent protein kinase), modulates cell survival and death and is altered in the brains of patients with Alzheimer’s disease (AD). In AD increased susceptibility of lymphocytes to apoptosis has been reported. Methods: We investigated the level of the kinases mTOR and PKR and the eukaryotic initiation factor 2α (eIF2α) in lymphocytes of patients with AD in comparison with controls. In AD patients we also looked for a correlation between activated proteins and cognitive and memory tests. Results: We report significant alterations of the levels of these kinases and eIF2α in lymphocytes of AD patients that were also significantly correlated with cognitive and memory test scores. Conclusion: These results suggest that the levels of mTOR, PKR and eIF2α in lymphocytes could follow the cognitive decline in AD.
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hal-04034951 , version 1 (17-03-2023)

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Marc Paccalin, Stéphanie Pain-Barc, Claudette Pluchon, Chloé Paul, Marie-Noelle Besson, et al.. Activated mTOR and PKR Kinases in Lymphocytes Correlate with Memory and Cognitive Decline in Alzheimer’s Disease. Dementia and Geriatric Cognitive Disorders, 2006, 22 (4), pp.320-326. ⟨10.1159/000095562⟩. ⟨hal-04034951⟩
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