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Article Dans Une Revue Cell Reports Année : 2022

Striatum expresses region-specific plasticity consistent with distinct memory abilities

Jonathan Touboul
  • Fonction : Auteur
Sylvie Perez
  • Fonction : Auteur
Yihui Cui
  • Fonction : Auteur
Gaëtan Vignoud
  • Fonction : Auteur
Elodie Perrin
  • Fonction : Auteur
Alexandre Mendes
  • Fonction : Auteur
Zhiwei Zheng
  • Fonction : Auteur

Résumé

The striatum mediates two learning modalities: goal-directed behavior in dorsomedial (DMS) and habits in dorsolateral (DLS) striata. The synaptic bases of these learnings are still elusive. Indeed, while ample research has described DLS plasticity, little remains known about DMS plasticity and its involvement in procedural learning. Here, we find symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in DMS and DLS, respectively, with opposite plasticity dominance upon increasing corticostriatal activity. During motor-skill learning, plasticity is engaged in DMS and striatonigral DLS neurons only during early learning stages, whereas striatopallidal DLS neurons are mobilized only during late phases. With a mathematical modeling approach, we find that symmetric anti-Hebbian STDP favors memory flexibility, while asymmetric anti-Hebbian STDP favors memory maintenance, consistent with memory processes at play in procedural learning.
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Dates et versions

hal-04028431 , version 1 (14-03-2023)

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Jonathan Touboul, L. Venance, Sylvie Perez, Yihui Cui, Gaëtan Vignoud, et al.. Striatum expresses region-specific plasticity consistent with distinct memory abilities. Cell Reports, 2022, 38 (11), pp.110521. ⟨10.1016/j.celrep.2022.110521⟩. ⟨hal-04028431⟩
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