The one-directional three-component wave propagation in a T-shaped soil domain (1DT-3C) is a numerical modeling technique, in a finite element scheme, to investigate dynamic soil-structure interaction (SSI) coupled with seismic site effects, under the assumption of vertical propagation of three-component seismic motion along a horizontal multilayered soil. A three-dimensional elasto-plastic model is adopted for soils, characterized using their shear modulus reduction curve. In this research, the 1DT-3C wave propagation modeling technique is proposed as an efficient tool for bridge design to take into account directly the spatial variability of seismic loading. This approach, in the preliminary phase of bridge study and design, allows the reduction of the soil domain and the easier definition of boundary conditions, using geotechnical parameters obtained with only one borehole investigation for each pier. This leads to a gain in modeling and computational time.