In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2022

In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

Résumé

Pulmonary infections with Acinetobacter baumannii are often difficult to treat due to multidrug resistance. Furthermore, the presence of mucin (main component of mucus) in lung has been shown to decrease polymyxin activity (Huang JX et al., 2015 Antimicrob Agents Chemother). The aim of this study was to characterize the effect of mucin on polymyxin B (PMB) activity against A. baumannii in vitro, using a PK/PD modelling approach.

Domaines

Pharmacologie
Fichier principal
Vignette du fichier
Poster_Lacroix M.pdf (2.08 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04016532 , version 1 (06-03-2023)

Identifiants

  • HAL Id : hal-04016532 , version 1

Citer

Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩

Collections

UNIV-POITIERS PHAR
14 Consultations
7 Téléchargements

Partager

Gmail Facebook X LinkedIn More