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Article Dans Une Revue International Dairy Journal Année : 2006

Immunomodulating effects of water-soluble extracts of traditional French Alps cheeses on a human T-lymphocyte cell line

Résumé

The immunomodulation potential of four pressed-curd cheeses was studied in vitro on human T lymphocytes. T lymphocyte proliferation and metabolic activity were evaluated with optimized 5-bromo-2′-deoxyuridine and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assays, respectively. The up to 4.6-fold stimulation of T-lymphocyte proliferation and metabolic activity by Abondance and Tomme de Savoie water-soluble extracts (WSEs) at the lag phase suggested the presence of immunomodulating compounds in these cheeses. Since peptides released from milk proteins during cheesemaking are potential immunomodulatory compounds, the high-performance liquid chromatography peptide profiles of the cheese WSEs were determined. While no correlation between peptide composition and in vitro immunomodulation of T-lymphocyte cells could be established, peptide quantity, size and hydrophobicity were related to cheesemaking technological parameters such as cheese age and cooking temperature.

Dates et versions

hal-04008586 , version 1 (28-02-2023)

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Citer

Christèle Durrieu, Pascal Degraeve, Stéphane Chappaz, Adèle Martial-Gros. Immunomodulating effects of water-soluble extracts of traditional French Alps cheeses on a human T-lymphocyte cell line. International Dairy Journal, 2006, 16 (12), pp.1505-1514. ⟨10.1016/j.idairyj.2005.10.015⟩. ⟨hal-04008586⟩
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