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Article Dans Une Revue Progress in Neuro-Psychopharmacology and Biological Psychiatry Année : 2018

The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients

Khalil El Asmar
  • Fonction : Auteur
Denis David
Alain Gardier
  • Fonction : Auteur
Laurent Becquemont
  • Fonction : Auteur
Bruno Fève
  • Fonction : Auteur
  • PersonId : 1088501
  • IdHAL : bruno-feve
Céline Verstuyft
  • Fonction : Auteur
Emmanuelle Corruble

Résumé

The study of genetic polymorphisms involved in antidepressants (AD) response is essential to provide a personalized medicine approach in the field of depression. β-arrestin 2 (ARRB2) is a candidate gene in the pharmacogenetics of AD as it is involved in the signaling cascade downstream of numerous neurotransmitter receptors. We investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to AD treatment in a sample of 569 patients with a major depressive episode treated for 6 months. We show that GG/GT patients for rs4522461 (n = 534) and AA/AC patients for rs4790694 (n = 244) have a lower response to AD than other genotype groups (HDRS score of 10.9 vs 8.0 after 6 months, multivariate analysis: p = 0.03; 12.2 vs 9.6, p = 0.02, respectively). These data provide additional evidence that β-arrestin 2 is a regulator of intracellular signal transduction processes involved in AD treatment.
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Dates et versions

hal-04006827 , version 1 (27-02-2023)

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Citer

Anne-Cécile Petit, Khalil El Asmar, Denis David, Alain Gardier, Laurent Becquemont, et al.. The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2018, 81, pp.74-79. ⟨10.1016/j.pnpbp.2017.10.006⟩. ⟨hal-04006827⟩
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