The recent excavations at the site of Molali, located in southern Uzbekistan and dated to the mid-second millennium BCE, offer new insights into the definition of the Final Bronze Age pottery complex in southern Uzbekistan and the technological and stylistic links between the potting traditions of the various cultural groups at this period. An archaeometric study has been conducted in order to characterize the various wares, investigate the compositional variability of the ceramic assemblage, and determine the provenance of the raw materials. The results from a combination of techniques (Wavelength Dispersive X-Ray Fluorescence, X-Ray Diffraction, and thin section Optical Microscopy) allowed us to identify a local pottery production of wheel-made fine ware and to determine the local/regional origin of the handmade, coarse, shell-tempered ware. Exchange relationships with ‘steppe’ populations have been confirmed; they involved not only vessels (coarse rock-tempered pots) but also pottery traditions (specific ‘steppe’-like decorations on pots of regional origin). Although not numerous, they are nonetheless evidence of large-scale connections between the settlements in the Surkhan Darya valley and other peripheral cultures and areas in the mid-second millennium BCE. The diversity of fabrics (use of various raw materials and different technological processes) is also discussed regarding the choices made for intrinsic material properties required for specific functions, highlighting the strong expertise and management acquired by the potters for the production of diverse ceramic functional categories.