Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains - Archive ouverte HAL Access content directly
Journal Articles FEBS Letters Year : 1995

Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains

Abstract

MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.

Dates and versions

hal-04001494 , version 1 (22-02-2023)

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Catherine Tomasetto, Christel Moog-Lutz, Catherine H. Régnier, Valerie Schreiber, Paul Basset, et al.. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. FEBS Letters, 1995, 373 (3), pp.245-249. ⟨10.1016/0014-5793(95)01040-l⟩. ⟨hal-04001494⟩
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