An impedimetric immunosensor based on PAMAM decorated electrospun polystyrene fibers for detection of interleukin-10 cytokine - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Electroanalytical Chemistry Année : 2022

An impedimetric immunosensor based on PAMAM decorated electrospun polystyrene fibers for detection of interleukin-10 cytokine

Résumé

Cytokine storms are known as the uncontrolled overproduction of inflammatory cytokines that can be produced by a variety of viral or non-infectious disorders and inflict significant damage to many organs. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and rapid detection of its levels in serum and saliva electrode but also the active surface area available for covalently binding of anti-IL-10 capture antibody, resulting in the sensitive detection of AgIL-10 in the concentration range of (1-50 pg/mL) in phosphate buffer saline (PBS) with a limit of detection (LOD) of 1 pg/mL. The immunosensor's performance in detecting AgIL-10 in artificial saliva (AS) as a complex medium was likewise satisfactory. This immunosensor provides a new opportunity for clinical immunoassays thanks to its great sensitivity, selectivity, and stability.
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Dates et versions

hal-03996688 , version 1 (20-02-2023)

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Pouyan Razmshoar, S. Hajir Bahrami, Mohammad Rabiee, Isaac A.M. Frias, Marie Hangouet, et al.. An impedimetric immunosensor based on PAMAM decorated electrospun polystyrene fibers for detection of interleukin-10 cytokine. Journal of Electroanalytical Chemistry, 2022, 926, pp.116953. ⟨10.1016/j.jelechem.2022.116953⟩. ⟨hal-03996688⟩
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