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Article Dans Une Revue (Data Paper) Hemato Année : 2022

Persisting Endothelial Cell Activation and Hypercoagulability after COVID-19 Recovery—The Prospective Observational ROADMAP-Post COVID-19 Study

Patrick van Dreden
  • Fonction : Auteur
Theodoros Sergentanis
  • Fonction : Auteur
Marianna Politou
  • Fonction : Auteur
Aurélie Rousseau
  • Fonction : Auteur
Matthieu Grusse
  • Fonction : Auteur
Michèle Sabbah
Ismail Elalamy
  • Fonction : Auteur
Vasiliki Pappa
  • Fonction : Auteur
Tina Skourti
  • Fonction : Auteur
Tina Bagratuni
Ioannis Ntanasis-Stathopoulos
Eleni Korompoki
  • Fonction : Auteur
Stavroula Labropoulou
  • Fonction : Auteur
Meletios Dimopoulos
Evangelos Terpos

Résumé

Background. Hypercoagulable state and endothelial cell activation are common alterations in patients with COVID-19. Nevertheless, the hypothesis of persistent hypercoagulability and endothelial cell activation following recovery from COVID-19 remains an unresolved issue. Objectives. To investigate the persistence of endothelial cell activation and hypercoagulability after recovery from COVID-19. Patients/Methods. COVID-19 survivors (n = 208) and 30 healthy individuals were enrolled in this study. The following biomarkers were measured: procoagulant phospholipid-dependent clotting time (PPL-ct), D-Dimer, fibrin monomers (FM), free Tissue factor pathway inhibitor (free-TFP)I, heparinase, and soluble thrombomodulin (sTM). Antibodies against SARS-CoV-2 (IgG and IgA) were also measured. Results. The median interval between symptom onset and screening for SARS-CoV-2 antibodies was 62 days (IQR = 22 days). Survivors showed significantly higher levels of D-Dimers, FM, TFPI, and heparanase as compared to that of the control group. Survivors had significantly shorter PPL-ct. Elevated D-dimer was associated with older age. Elevated FM was associated with female gender. Elevated heparanase was independently associated with male gender. Decreased Procoag-PPL clotting time was associated with female gender. One out of four of COVID-19 survivors showed increase at least one biomarker of endothelial cell activation or hypercoagulability. Conclusions. Two months after onset of COVID-19, a significant activation of endothelial cells and in vivo thrombin generation persists in at least one out of four survivors of COVID-19. The clinical relevance of these biomarkers in the diagnosis and follow-up of patients with long COVID-19 merits to be evaluated in a prospective clinical study.

Dates et versions

hal-03994577 , version 1 (17-02-2023)

Identifiants

Citer

Grigorios Gerotziafas, Patrick van Dreden, Theodoros Sergentanis, Marianna Politou, Aurélie Rousseau, et al.. Persisting Endothelial Cell Activation and Hypercoagulability after COVID-19 Recovery—The Prospective Observational ROADMAP-Post COVID-19 Study. Hemato, 2022, 3 (1), pp.111-121. ⟨10.3390/hemato3010010⟩. ⟨hal-03994577⟩
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