The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor - Archive ouverte HAL Access content directly
Journal Articles Cell Year : 1994

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

Richard Roy
  • Function : Author
Jörg P. Adamczewski
  • Function : Author
Thierry Seroz
  • Function : Author
Wim Vermeulen
  • Function : Author
Jean-Pierre Tassan
  • Function : Author
Laurent Schaeffer
  • Function : Author
Erich A. Nigg
  • Function : Author
Jan H. J. Hoeijmakers
  • Function : Author

Abstract

A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.

Dates and versions

hal-03991564 , version 1 (15-02-2023)

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Richard Roy, Jörg P. Adamczewski, Thierry Seroz, Wim Vermeulen, Jean-Pierre Tassan, et al.. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell, 1994, 79 (6), pp.1093-1101. ⟨10.1016/0092-8674(94)90039-6⟩. ⟨hal-03991564⟩
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