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Article Dans Une Revue Infectious Diseases Now Année : 2022

Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months

Résumé

Objectives : We aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital. Methods : Determination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7 months. Results : We included 3062 HCWs; 256 (8.4%) were positive for anti-SARS-CoV-2 nucleocapsid IgG. Among them, early decrease in the anti-nucleocapsid antibody index was observed between the first (S1) and second (S2) serology samplings in 208 HCWs (84.2%). The initial anti-nucleocapsid IgG index seemed to be related to the HCWs' age. Seventy-four HCWs were included in the 7-month cohort study. Among them, 69 (90.5%) had detectable anti-spike IgG after 7 months and 24 (32.4%) reported persistent symptoms consistent with post-acute COVID-19 syndrome diagnosis. Conclusion : The prevalence of serological positivity among HCWs was 6.7%. Infection should be followed by vaccination because of antibody decrease.

Dates et versions

hal-03983231 , version 1 (10-02-2023)

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Benoît Pilmis, I. Elkaibi, G. Péan de Ponfilly, H. Daikha, A. Bouzid, et al.. Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months. Infectious Diseases Now, 2022, 52 (2), pp 68-74. ⟨10.1016/j.idnow.2022.01.004⟩. ⟨hal-03983231⟩
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