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Article Dans Une Revue Scientific Reports Année : 2018

Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids

Peter Seeber
Sanatana-Eirini Soilemetzidou
  • Fonction : Auteur
Walid Azab
Julia Bohner
  • Fonction : Auteur
Bayarbaatar Buuveibaatar
  • Fonction : Auteur
Gábor Á. Czirják
  • Fonction : Auteur
Marion East
  • Fonction : Auteur
Eva Maria Greunz
  • Fonction : Auteur
Petra Kaczensky
Benjamin Lamglait
  • Fonction : Auteur
Jörg Melzheimer
  • Fonction : Auteur
Kenneth Uiseb
  • Fonction : Auteur
Alix Ortega
  • Fonction : Auteur
Nikolaus Osterrieder
  • Fonction : Auteur
Ditte-Mari Sandgreen
  • Fonction : Auteur
Marie Simon
  • Fonction : Auteur
Chris Walzer
  • Fonction : Auteur
Alex Greenwood
  • Fonction : Auteur

Résumé

Abstract Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse ( Equus ferus caballus ) and of both captive and free-ranging Mongolian khulan ( Equus hemionus hemionus ) and plains zebra ( Equus quagga ). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations.

Dates et versions

hal-03975633 , version 1 (06-02-2023)

Identifiants

Citer

David Costantini, Peter Seeber, Sanatana-Eirini Soilemetzidou, Walid Azab, Julia Bohner, et al.. Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids. Scientific Reports, 2018, 8 (1), pp.10347. ⟨10.1038/s41598-018-28688-0⟩. ⟨hal-03975633⟩

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