Behavioral effect of selective deletion of beta2* nicotinic acetylcholine receptors in neuropeptide Y expressing interneurons
Résumé
Neuropeptide Y (NPY) is an abundant neuropeptide in the neocortex involved in numerous processes. NPY-expressing neurons differ in electrophysiological, molecular and morphological properties but overall, they are GABAergic interneurons (GINs). All cortical layers receive cholinergic inputs from the basal forebrain, which are crucial for cognition. Cholinergic receptors are differentially distributed across the cortex and the activation of nicotinic acetylcholine receptors (nAChRs) located on principal neurons and GINs modulates synaptic plasticity and behavior.
Domaines
Neurosciences [q-bio.NC]| Origine | Fichiers produits par l'(les) auteur(s) |
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