Deletion of beta2* nicotinic acetylcholine receptors in striatal GABAergic interneurons alters behavior of conditional knockout mice - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2021

Deletion of beta2* nicotinic acetylcholine receptors in striatal GABAergic interneurons alters behavior of conditional knockout mice

Résumé

Neuropeptide Y (NPY) is an abundant neuropeptide in the neocortex involved in numerous processes. NPY-expressing neurons differ in electrophysiological, molecular and morphological properties but overall, they are GABAergic interneurons (GINs). All cortical layers receive cholinergic inputs from the basal forebrain, which are crucial for cognition. Cholinergic receptors are differentially distributed across the cortex and the activation of nicotinic acetylcholine receptors (nAChRs) located on principal neurons and GINs modulates synaptic plasticity and behavior.
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hal-03972928 , version 1 (03-02-2023)

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  • HAL Id : hal-03972928 , version 1

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Alice Abbondanza, Irina Ribeiro Bas, Martin Modrak, Jessica Minich, Alexandra Tyshkevich, et al.. Deletion of beta2* nicotinic acetylcholine receptors in striatal GABAergic interneurons alters behavior of conditional knockout mice. NeuroFrance 2021, May 2021, Online, France. ⟨hal-03972928⟩
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