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Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2023

Drug candidates targeting multidrug resistance in cancer and infections

Résumé

Multidrug resistance (MDR) is the phenomenon by which prokaryotic and eukaryotic cells have developed resistance to drugs. The SARSCov-19 pandemic has spotlighted the lethal effect of MDR in the context of nosocomial diseases. In this context, the MDR against anticancer drugs and antibiotics are by far the most investigated areas. MDR finds multiple origins including intracellular drug inactivation, biological target alteration, activation of DNA repair mechanisms (in the case of cancer) and drug expulsion from inside to outside the cells leading to drug concentration below the active threshold. In the latter case, the high expression of efflux proteins at the cell membrane plays a critical role in the transport and pumping out of drugs.

Dates et versions

hal-03972628 , version 1 (03-02-2023)

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Citer

Marc Le Borgne, Pierre Falson, Ahcène Boumendjel. Drug candidates targeting multidrug resistance in cancer and infections. European Journal of Medicinal Chemistry, 2023, 249, pp.115173. ⟨10.1016/j.ejmech.2023.115173⟩. ⟨hal-03972628⟩
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