Article Dans Une Revue Journal of Clinical Medicine Année : 2020

Child-Adult Transition in Sarcoidosis: A Series of 52 Patients.

Jean-François Bernaudin
  • Fonction : Auteur
  • PersonId : 1029284
Dominique Valeyre
  • Fonction : co dernier-auteur

Résumé

(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.

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Dates et versions

hal-03970116 , version 1 (02-02-2023)

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Simon Chauveau, Florence Jeny, Marie-Emeline Montagne, Rola Abou Taam, Véronique Houdouin, et al.. Child-Adult Transition in Sarcoidosis: A Series of 52 Patients.. Journal of Clinical Medicine, 2020, 9, ⟨10.3390/jcm9072097⟩. ⟨hal-03970116⟩
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